We develop technologies and computational methods to answer big questions in biology that were previously inaccessible. Why do mom and dad have different interests in the expression of certain genes in their offspring? Can changes in gene expression alone cause cancer? What is the cause of schizophrenia? How can we identify good drug targets? Can we use algae to clean up contaminated water? Why did mammals evolve a complex program to silence certain genes? To get at these, and other questions, we are developing wet and dry lab tools that give us unprecedented insight into the underlying science.