Multiauthor volumes (1966-2010)

l. D. R. Forsdyke.  Proceedings of Symposium on "The Biological Effects of Phytohaemagglutinin", Ed. Elves, M.W., The R. Jones & A. Hunt Orthopaedic Hospital, Oswestry, England, p. ll5-l23. "Nucleic acid changes during PHA-induced lymphocyte transformation in vitro, and the possible relationship of this phenomenon to immune processes in vivo" (l966).

2. P. Milthorp and D. R. Forsdyke.  Proceedings 5th Leukocyte Culture Conference  Ed. Harris, J. Academic Press, N.Y., p. l43-l7l.  "Activation by Con A and PHA of rat lymphocytes in homologous or heterologous serum: dependence of inhibition at high Con A/serum ratios on complement (l970b).

3. D. R. Forsdyke.  Proceedings 11th Leukocyte Culture Conference  Ed. D. O. Lucus, Academic Press, New York, 730-732.  Serum factors affecting the incorporation of [³H]thymidine by lymphocytes stimulated by antigen:  IV. Increased divergence between antigen dose-response curves in heated and control serum with rabbits immunized to increase the proportion of high specificity cells (l977c). Click Here

4. D. R. Forsdyke & F.W. Scott.  In: Cell Compartmentation and Metabolic Channelling  Ed. Lynen, F., Mothes, K., & Nover, L.  Elsevier, Amsterdam. pp. l77-l84.  "Exogenous purine deoxyribonucleosides do not prevent inhibition of DNA synthesis by hydroxyurea: evidence for nonconvergence of de novo and salvage pathways." (l979c).

5. D. R. Forsdyke. Proceeding l3th Leukocyte Culture Conference  Ed. Kaplan, J. G., Elsevier, Amsterdam. pp. 355-360. "Colchicine inhibits the early enhancement of [³H]uridine incorporation in lymphocytes activated by high concentrations of concanavalin-A (l979d).

6. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 11, 537-539 (2002). Gregor Mendel.  (also Nature Encyc. Hum. Genome. 2003) Click Here

7. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 3, 115-117 (2002). William Bateson.   (also Nature Encyc. Hum. Genome. 2003) Click Here

8. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 16, 605-606 (2002). George Romanes. Click Here

9. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 12, 398-400 (2002). H.J. Muller. Click Here

10. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 8, 445-447 (2002). J.B.S. Haldane. (also Nature Encyc. Hum. Genome. 2003) Click Here

11. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 4, 239-240 (2002). E. Chargaff. Click Here

12. D. R. Forsdyke. Nature Encyclopedia of Life Sciences 7, 396-403 (2002). Functional constraint and molecular evolution. Click Here  

13. D. R. Forsdyke. In: Lewin's GENES X (2010) Editors:  J. E. Krebs, S. T. Kilpatrick & E. S. Goldstein. DRF edited and updated Chapter 4 ("The Interrupted Gene"), and Section 6 of Chapter 8 ("How Did Interrupted Genes Evolve?") (Click Here)  

Papers in Refereed Journals (1966-1992)

Lectin-Activation of Cultured Lymphocytes - Role of Serum Factors - RNA and DNA Synthesis

1. Quantitative nucleic acid changes during PHA-induced lymphocyte transformation in vitro:
dependence of the response on the PHA/serum ratio. D.R. Forsdyke. Biochem. J. l05, 679-684 (l967). Click Here

2. The liquid scintillation counter as an analogy for the distinction between "self" and "not-self" in immunological systems. D.R. Forsdyke. Lancet, l, 28l-283 (l968a). Click Here

3. Studies of the incorporation of 5-[³H]uridine during activation and transformation of lymphocytes induced by phytohaemagglutinin: dependence of the incorporation rate on uridine concentration at certain critical concentrations. D.R. Forsdyke. Biochem. J. l07, l97-205 (l968b). Click Here

4. Incorporation of [³H]-uridine and attachment of cells to glass during activation of lymphocytes induced by PHA. D.R. Forsdyke. Biochem. J. l08, 297-302 (l968c). Click Here

5. A theory of immunity. D. R. Forsdyke. J. Theoret. Biol. 25, l73-l85 (l969a).

6. Impaired activation of thymus lymphocytes by PHA.  D. R. Forsdyke. J. Immunol. l03, 8l8-823 (l969b).

7. Inhibition of lymphocyte activation at high ratios of Con A to serum depends on complement.  P. Milthorp and D. R. Forsdyke. Nature 227, 1351-1352 (l970a).

8. Application of the isotope dilution principle to the analysis of factors affecting the incorporation of [³H]uridine and [³H]cytidine into cultured lymphocytes: evaluation of pools in serum and culture media.  D. R. Forsdyke. Biochem. J. l25, 72l-732 (l97l). Click Here  

9. Isotope dilution analysis of cell stimulation or inhibition by biological media. D. R. Forsdyke & P. Milthorp. J. Immunol. Methods, l, 207-209 (l972a).

l0. Immunological defect in Whipple's disease.  A. Groll, L. Valberg, J. Simon, D. Eidinger, B. Wilson and D. R. Forsdyke. Gastroenterology, 63, 943-950 (l972b).

11. Serum factors affecting the incorporation of [³H]uridine by lymphocytes stimulated by concanavalin-A:  studies of the role of complement.  P. Milthorp & D. R. Forsdyke. Biochem. J. l32, 803-8l2 (l973a). Click Here 

l2. A comparison of the activation of thymus and lymph-node cells by concanavalin-A and phytohaemagglutinin.  P. Milthorp and D. R. Forsdyke. J. Immunol. Methods 2, 269-277 (l973b).

l3. Serum and lymphocyte activation by phytohaemagglutinin. D. R. Forsdyke. Exp. Cell Research 77, 2l6-222 (l973c).

l4. Serum factors affecting the incorporation of [³H]thymidine by lymphocytes stimulated by antigen:  I. Serum concentration. D. R. Forsdyke. Immunology 25, 583-596 (l973d). Click Here

l5. Serum factors affecting the incorporation of [³H]thymidine by lymphocytes stimulated by antigen:  II.  Evidence for a role of complement from studies with heated serum. D.R. Forsdyke. Immunology 25, 597-6l2 (l973e). Click Here

l6. Serum factors affecting the incorporation of [³H]thymidine by lymphocytes stimulated by antigen:  III. Evidence for a role of complement from studies with specific complement inhibitors.  D. R. Forsdyke  Immunology 25, 6l3-6l9 (l973f). Click Here

l7. Isotope dilution analysis of rate-limiting steps and pools affecting the incorporation of thymidine and deoxycytidine into cultured thymus cells. D. A. Sjostrom & D. R. Forsdyke.  Biochem. J. l38, 253-262  (l974). Click Here  

l8. Further implications of a theory of immunity.  D. R. Forsdyke.  J. Theoret. Biol. 52, l87-l98 (l975a). Click Here

l9. Evidence for a relationship between chloroquine and complement:  Possible implications for the mechanism of action of chloroquine in disease.  D. R. Forsdyke. Can. J. Microbiol. 2l, l58l-l586 (l975b).

20. Isotope dilution studies of the effects of 5-fluorodeoxyuridine and hydroxyurea on the incorporation of deoxycytidine and thymidine by cultured thymus cells.  F.W. Scott & D. R. Forsdyke.  Can. J. Biochem. 54, 238-248 (l976).

2l. Stimulation by autologous serum preheated at 66°C of the incorporation of [³H]uridine by cultured  lymphocytes:  comparison with stimulation by concanavalin-A.  C. M. David & D. R. Forsdyke. Can. J. Biochem. 55, 2l5-222 (l977a).

22. Role of receptor aggregation in complement-dependent inhibition of lymphocytes by high concentrations of Con-A.  D. R. Forsdyke. Nature, 267, 358-360 (l977b).

23. Role of complement in the toxicity of dietary legumes.  D. R. Forsdyke. Medical Hypothesis, 4, 97-l00 (l978a).

24. The rate of DNA synthesis by cultured Chinese Hamster ovary cells: an application of isotope dilution analysis.  F.W. Scott & D. R. Forsdyke. Biochem. J. l70, 545-549 (l978b). Click Here 

25. Comparison of enhancement by heated serum and 2-mercaptoethanol of lymphocyte transformation induced by high concentrations of concanavalin-A.  D. R. Forsdyke & C. M. David. Cellular Immunology, 36, 86-96 (l978c).

26. Serum factors affecting the incorporation of [³H]thymidine by lymphocytes stimulated by antigen.  IV. Comparison of enhancement by heated (56°C) serum and by 2-mercaptoethanol.  D. R. Forsdyke.  Int. Arch. Allergy Appl. Imm. 60, 89-96 (l979a).

27. Early-onset inhibition of lymphocytes in heterologous serum by high concentrations of concanavalin-A. Further studies of the role of complement with suramin and heated serum. D. R. Forsdyke and P. Milthorp.  Int. J. Immunopharmacology l, l33-l39 (l979b).

28. Isotope dilution analysis of the effects of deoxyguanosine and deoxyadenosine on the incorporation of  thymidine and deoxycytidine by hydroxyurea-treated thymus cells.  F. W. Scott and D. R. Forsdyke. Biochem. J. l90, 72l-730 (l980a). Click Here

29. Lectin pulses as determinants of lymphocyte activation and inactivation during the first six hours of culture: sequential action of concanavalin-A and complement cause cell lysis.  D. R. Forsdyke. Canad. J.  Biochem. 58, l387-l396 (l980b).

30. Are introns in-series error detecting sequences?  D. R. Forsdyke.  J. Theoret. Biol. 93, 861-866 (1981). Click Here

Membrane Lipids and Cell Aggregation Phenomena

31. Role of serum in inhibition of cultured lymphocytes by lysophosphatidylcholine.  A. Takeda, R. G. E. Palfree & D. R. Forsdyke. Biochim. Biophys. Acta 710, 87-98 (1982a).

32. Formation of erythrocyte rouleaux in preheated normal serum:  roles of albumin polymers and       lysophosphatidylcholine.  D. R. Forsdyke, R. G. E. Palfree & A. Takeda. Canad. J. Biochem. 60, 705-711 (1982b).

33. Rouleau formation as a measure of the phase-separating ability of plasma.  D. R. Forsdyke & P.M. Ford.  J. Theoret. Biol. 103, 467-472 (1983a).

34. Segregation into separate rouleaux of erythrocytes from different species: evidence against the agglomerin hypothesis of rouleaux formation. D. R. Forsdyke & P. M. Ford.  Biochem. J. 214, 257-260  (1983b). Click Here   

Complementary DNA Cloning and Characterization of Lymphocyte Activation "G0S" Genes

35. Purification of Oligo dG-tailed Okayama-Berg linker DNA fragments by oligo[dC]cellulose chromatography. D. R. Forsdyke.  Anal. Biochem. 137, 143-145 (1984a).

36. Rapid qualitative changes in mRNA populations in cultured human lymphocytes: comparison of the effects of cycloheximide and concanavalin-A.  D. R. Forsdyke. Canad. J. Biochem. 62, 859-865 (1984b).

37. cDNA cloning of mRNAs which increase rapidly in human lymphocytes cultured with concanavalin-A and cycloheximide.  D. R. Forsdyke. Biochem. Biophys. Res. Comm. 129, 619-625 (1985a). [G0S19, G0S30]

38. Heat shock proteins defend against intracellular pathogens: a non-immunological basis for self/non-self discrimination. D. R. Forsdyke. J. Theoret. Biol. 115, 471-473 (1985b). Click Here

39. A set of human putative lymphocyte G0/G1 switch genes includes genes homologous to rodent cytokine and zinc finger protein-encoding genes. Siderovski, D. P., Blum, S., Forsdyke, R. E. & Forsdyke, D. R. DNA Cell Biol. 9, 579-587 (1990a). [more G0S genes] Click Here

44. Two signal model of self/not-self immune discrimination: an update. Forsdyke, D. R. J. Theoret. Biol. 154, 109-118. (1992). Click Here