Papers selected in 2017

Papers selected 2017

PTEN interacts with DAXX and, in turn PTEN directly regulates oncogene expression by modulating DAXX-H3.3 association on the chromatin, independently of PTEN enzymatic activity. Furthermore, DAXX inhibition specifically suppresses tumour growth. 

The selfish gene element   is made up of sup-35, a maternal-effect toxin that kills developing embryos, and pha-1, its zygotically expressed antidote. pha-1 has long been considered essential for pharynx development on the basis of its mutant phenotype, but this phenotype arises from a loss of suppression of sup-35 toxicity.

EphA2 SAM domain inhibits kinase activity by reducing receptor oligomerization

The pre-Brenner history of using C. elegans and other nematodes as model organisms.

AMPK is required to block germ-line gene expression during starvation. In its absence the inappropriate activation of germ-line transcription results in sterility and transgenerational reproductive defects.

Using CRISPR they deleted genes that mice need to grow certain organs. When they introduced rat stem cells capable of producing those organs, those cells flourished and the chimeric mouse-rat lived to adulthood.  Interestingly rats do not make gallbladders (mice do) and the mouse cells could induce the rat stem cells to make gallbladders. Although very inefficient,  Human-pig chimeric embryos were also made but terminated after 28 days of development. 

Review on Sleep in C. elegans.

Heat and oxidative stress in combination with Hsp90 knockdown (daf-21 RNAi) caused transposon excision and transposition in C. elegans.