The Chin-Sang Lab Reads
2006 and Older
Regulation of germline proliferation by nutrient sensing.
Force sensing in the cell by Src kinase
at least watch this movie:
Supplementary Video 4 (mov 22,862 K)
Time-lapse sequence of a 2-dpf Tg(nkx2.2a:megfp) embryo following ablation of three dorsally migrated EGFP+ OPCs. Nearby OPCs in dorsal and ventral spinal cord extend multiple processes into the ablated region and migrate into the area. Images were collected every 2 min, and the movie runs at 5 frames per second. Dorsal is up and anterior left.
Can dSRNA cause gene activation?
VAB-1 has a new binding partner: WRK-1
Science special online collection: Genomic Evolution: Building the Body from Genes
Tobias Sjöblom et al.
~3 million PCRs sequenced! Building a Cancer gene consensus.
Supplementary tables Breast Cancer genes and Colorectal Cancer genes
Note that Eph receptors were identified as candidate cancer genes
See similar research Wood et al. 2007 here
Viruses that infect mammalian cells can infect C. elegans and replicate.
[Link to Nature Genetics] [Supplementary Information]
Ogura and Goshima show that the UNC-5 receptor sub-cellular localization is regulated by UNC-51 and UNC-14
follow up letter (July 14h 2006):
Are there differences in the recognition specificities of the SH2 domains of Nck1 and Nck2?
Drosophila null Eph receptor mutants do not have severe axon guidance defect in contrast to previous RNAi results. Like C. elegans this suggest genetic redundancy in axon guidance. However these authors report Drosophila Eph/ephrin signaling plays roles in axon branches. Drosophila now joins C. elegans in which large genetic screens to identify genes involved in Eph/ephrin Signaling.
What more can model organism tell us about fundamental biological processes? Here is a link to a recent Science research spot light by Fields and Johnston. [PDF]
"Genetics is not only compatiable with systems biology, it is a corner stone of any useful for of it."
Research grants: The nightmare before funding.
Scientist agree that human activities are contributing to global climate change.
Suspended Embryo Mount for Imaging Caenorhabditis elegans
January 23, 2004: 116 (2)
"30 Years of Exciting Biology"
Full text of the original research articles is available via the online supplement: Cell: 116(s2)
Classic C. elegans Papers
