2006 and Older

 Regulation of germline proliferation by nutrient sensing.


 Force sensing in the cell by Src kinase

at least watch this movie:

Supplementary Video 4 (mov 22,862 K)
Time-lapse sequence of a 2-dpf Tg(nkx2.2a:megfp) embryo following ablation of three dorsally migrated EGFP+ OPCs. Nearby OPCs in dorsal and ventral spinal cord extend multiple processes into the ablated region and migrate into the area. Images were collected every 2 min, and the movie runs at 5 frames per second. Dorsal is up and anterior left.













Can dSRNA cause gene activation?















VAB-1 has a new binding partner: WRK-1




Science special online collection: Genomic Evolution: Building the Body from Genes






Tobias Sjöblom  et al.

 ~3 million PCRs sequenced!  Building a  Cancer gene consensus.

Supplementary tables  Breast Cancer genes and Colorectal Cancer genes

Note that Eph receptors were identified as candidate cancer genes

See  similar research Wood et al. 2007 here







 Viruses that infect mammalian cells can infect C. elegans and replicate.


[Link to Nature Genetics]  [Supplementary Information]


 Ogura and Goshima show that the UNC-5 receptor sub-cellular localization is regulated by UNC-51 and UNC-14




























follow up letter (July 14h 2006):












 Are there differences in the recognition specificities of the SH2 domains of Nck1 and Nck2?




Drosophila null Eph receptor mutants do not have severe axon guidance defect in contrast to previous RNAi results. Like C. elegans this suggest genetic redundancy in axon guidance.  However these authors report Drosophila  Eph/ephrin signaling plays roles in axon branches. Drosophila now joins C. elegans in which large genetic screens to identify genes involved in Eph/ephrin  Signaling.





What more can model organism tell us about fundamental biological processes? Here is a link to a recent Science research spot light by Fields and Johnston.  [PDF]








 "Genetics is not only compatiable with systems biology, it is a corner stone of any useful for of it."



  [Link to Neuron]    [PDF]




Research grants: The nightmare before funding.

Scientist agree that human activities are contributing to global climate change.

Suspended Embryo Mount for Imaging Caenorhabditis elegans

January 23, 2004: 116 (2)

"30 Years of Exciting Biology"
Full text of the original research articles is available via the online supplement: Cell: 116(s2)


 Classic C. elegans Papers


Latest Eph/Ephrin Reviews