Recent reviews on Ephrin and Eph Receptor Tyrosine Kinase Signaling: 

Latest review of Eph in stem cells and cancer.


Elena Pasquale reviews Eph Receptor signalling in cancer and highlights some of the new research that makes Eph receptors promising targets for cancer therapy. Note there is mention of our Eph/PTEN interaction in C. elegans.

Review on the roles of Eph signaling at the synapse








Ephrin signaling in axon guidance. Huot J (2004) Prog Neuropsychopharmacol Biol Psychiatry 28(5):813-8 [PDF]

Diverse Roles of Eph Receptors and Ephrins in the Regulation of Cell Migration and Tissue Assembly. Alexei Poliakov, Marisa Cotrina and David G. Wilkinson,Developmental Cell Volume 7, Issue 4 , October 2004, Pages 465-480  [PDF]

Eph/ephrin signaling in morphogenesis, neural development and plasticity. Rüdiger Klein, Current Opinion in Cell Biology Volume 16, Issue 5 , October 2004, Pages 580-589  [PDF]

Eph receptor–ephrin bidirectional signals that target Ras and Rho proteins. Nicole K. Noren a and Elena B. Pasquale. Cellular Signalling Volume 16, Issue 6 , June 2004, Pages 655-666 [PDF]

Eph receptors in the adult brain. Yu Yamaguchi and Elena B Pasquale. Current Opinion in Neurobiology, 2004, 14:3:288-296 [PDF]

Ephrin signaling: One raft to rule them all? One raft to sort them? One raft to spread their call and in signaling bind them? Gauthier LR, Robbins SM.Life Sci. 2003 Dec 5;74(2-3):207-16.  [PDF]

EphB receptors and ephrinB ligands: regulators of vascular assembly and homeostasis. Augustin HG, Reiss Y. Cell Tissue Res. 2003 Aug 2 [Epub ahead of print]

'Eph'ective signaling: forward, reverse and crosstalk. Keith K. Murai1,* and Elena B. Pasquale (2003). J Cell Sci. 2003 Jul 15;116(Pt 14):2823-32. [PDF]

Multiple roles of ephrins in morphogenesis, neuronal networking, and brain function. Amparo Palmer and Rudiger Klein(2003) Genes Dev. 2003 Jun 15;17(12):1429-50. Review.  [PDF]

Eph receptors and ephrins.Himanen and Nikolov (2003).
Int J Biochem Cell Biol. 2003 Feb;35(2):130-4. [PDF]

Eph signaling: a structural view. Himanen JP, Nikolov DB (2003).
Trends Neurosci. 2003 Jan;26(1):46-51. Review [PDF]

Diverse roles for the Eph family of receptor tyrosine kinases in carcinogenesis. Nakamoto and Bergemann (2002). Microsc Res Tech. 2002 Oct 1;59(1):58-67. Review. [PDF]

Eph family functions from an evolutionary perspective. Uwe Drescher (2002)
Curr Opin Genet Dev. 2002 Aug;12(4):397-402. Review. [PDF]

Ephrins in reverse, park and drive. Chad A. Cowan and Mark Henkemeyer (2002)
Trends Cell Biol. 2002 Jul;12(7):339-46. Review. [PDF]

Mechanisms and functions of Eph and ephrin signalling. Klas Kullander* and Rüdiger Klein‡ (2002). Nat Rev Mol Cell Biol. 2002 Jul;3(7):475-86. Review.  [PDF]

 Slide shows:

Nature Reviews Neuroscience 4; 941-956 (2003); doi:10.1038/nrn1254

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