Publications

             

 

Most recent publications:


 








2017

Jason C. Campbell, Ian D. Chin-Sang, William G. Bendena1 (2017).  A Caenorhabditis elegans Nutritional-status Based Copper Aversion Assay.  Journal of Visualized Experiments (JoVE).


2016

Walck-Shannon E, Lucas B, Chin-Sang I, Reiner D, Kumfer K, Cochran H, et al. (2016) CDC-42 Orients Cell Migration during Epithelial Intercalation in the Caenorhabditis elegans Epidermis. PLoS Genetics. http://dx.doi.org/10.1371/journal.pgen.1006415

Campbell JC, Polan-Couillard LF, Chin-Sang ID, Bendena WG (2016). NPR-9, a Galanin-Like G-Protein Coupled Receptor, and GLR-1 Regulate Interneuronal Circuitry Underlying Multisensory Integration of Environmental Cues in Caenorhabditis elegansPLoS Genet. 2016 May 25;12(5):e1006050. doi: 10.1371/journal.pgen.1006050. PMID: 27223098 

Shanqing Zheng and Ian D. Chin-Sang (2016). C. elegans Methods to Study PTEN. Methods in Molecular Biology. ISBN 978-1-4939-3299-3

2015

Jason C. Campbell, Ian D. Chin-Sang, and William G. Bendena (2015). Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch.  Peptides Volume 68, June 2015, Pages 164–174. doi:10.1016/j.peptides.2014.12.004

Liu J and Ian  Chin-Sang ID (2015).  C. elegans as a model to study PTEN's regulation and function.  Methods: Volumes 77–78, 1 May 2015, Pages 180–190.  doi:10.1016/j.ymeth.2014.12.009

2014

Jason C. Campbell, Ian D. Chin-Sang, William G. Bendena (2014). Mechanosensation circuitry in Caenorhabditis elegans: A focus on gentle touch. Peptides doi:10.1016/j.peptides.2014.12.004

Jun Liu , Ian D. Chin-Sang (2014). C. elegans as a model to study PTEN’s regulation and function. Methods. doi:10.1016/j.ymeth.2014.12.009

Qiang Wei, Jun Liu, Nan Wang, Xiaoying Zhang, Jin Jin, Ian Chin-Sang, Jimin Zhenga and Zongchao Jia (2014). Structures of an Eph receptor tyrosine kinase and its potential activation mechanism.   Biological Crystallography. PMID: 25478832

Pulido R, Baker SJ, Barata JT, Carracedo A, Cid VJ, Chin-Sang ID, Davé V, den Hertog J, Devreotes P, Eickholt BJ, Eng C, Furnari FB, Georgescu MM, Gericke A, Hopkins B, Jiang X, Lee SR, Lösche M, Malaney P, Matias-Guiu X, Molina M, Pandolfi PP, Parsons R, Pinton P, Rivas C, Rocha RM, Rodríguez MS, Ross AH, Serrano M, Stambolic V, Stiles B, Suzuki A, Tan SS, Tonks NK, Trotman LC, Wolff N, Woscholski R, Wu H, Leslie NR. A Unified Nomenclature and Amino Acid Numbering for Human PTEN. Science  Signaling. 2014 Jul 1;7(332)PMID: 24985344

Jun Liu, Stacy Visser-Grieve, Jeffrey Boudreau,  Benjamin Yeung, Samantha LoGabriel ChamberlainFabian Yu, Tao Sun, Tony PapanicolauAnnie Lam, Xiaolong Yang, Ian Chin-Sang (2014). Insulin Activates the Insulin Receptor to Down-regulate the PTEN Tumor Suppressor. Oncogene.

2013

Paul P. Su; Foroozan Torki;Tony PapanicolaouJeff R. Boudreau; Ian D. Chin-Sang; William G Bendena (2013 in revision). Caenorhabditis elegans neuropeptide genes nlp-5 and nlp-6 regulate locomotory and egg-laying behavior. PLoS ONE


Olivia MargieChris Palmer, and Ian Chin-Sang ( 2013)C. elegans Chemotaxis Assay. Journal of Visualized Experiments (JoVE)

Jordan D.S. Zelt, Ian D. Chin-Sang, Lois M. Mulligan (2013). A novel C. elegans animal model for human RET receptor function. [abstract]. In: Proceedings of the 104th Annual Meeting of the American Association for Cancer Research AACR; Cancer Res 2013;73(8 Suppl): doi:10.1158/1538-7445.AM2013-1580

2012

Allison Lynch, Theresa Grana, Elisabeth Cox-Paulson, Anabelle Couthier, Michel CameronIan Chin-Sang, Jonathan Pettitt, Jeff Hardin  (2012). A Genome-wide Functional Screen Shows MAGI-1 Is an L1CAM-Dependent Stabilizer of Apical Junctions in C. elegans.  Current Biology

Michael Miller and Ian Chin-Sang (2012). Eph Receptor Signaling in C. elegans. WormBook, ed. The C. elegans Research Community, WormBook. 

William G. Bendena, Jason CampbellLian Zara, Stephen S. Tobe and Ian D. Chin-Sang (2012). Select neuropeptides and their G-protein coupled receptors in Caenorhabditis elegans and Drosophila melanogasterFrontiers in Experimental Endocrinology 3:93.

Wang, C., Chin-Sang, I., Bendena, W.G. (2012) The FGLamide-allatostatins influence foraging behavior in Drosophila melanogasterPLoS ONE 7(4). 

Ahmed MohamedJeffrey BoudreauFabian Yu, Jun Liu and Ian D. Chin-Sang (2012). The Caenorhabditis elegans Eph receptor activates NCK and N-WASP, and inhibits Ena/VASP to regulate growth cone dynamics during axon guidance. PLoS Genetics 8(2). 

Li X, Johnson RW, Park D, Chin-Sang I, Chamberlin HM (2012). Somatic gonad sheath cells and Eph receptor signaling promote germ-cell death in C. elegans Cell Death Differ. 


Anita Fernandez, Annie Lam, and Ian Chin-Sang(2012) Real-time Embryogenesis in Live Caenorhabditis elegans Worms. The American  Physiological Society #R6064.


2011

Ahmed M. Mohamed and Ian D. Chin-Sang (2011). The C. elegans nck-1 gene encodes two isoforms and is required for neuronal guidance. Developmental Biology  354: 55-66

2009

Sarah BrisbinJun LiuJeff BoudreauJimmy PengMarie Evangelista, and Ian Chin-Sang (2009). A Role for C. elegans Eph RTK Signaling in PTEN Regulation. Developmental Cell 17(4) 459-469.  [PDF]  [Science Editor's Choice] [Must Read Faculty of 1000] [Top 25 Hottest Article]

Ian Chin-Sang and Weiwei Zhong (2009)Using LEDs as a low-cost source to detect GFP and DsRED. Worm Breeder's Gazette  Volume 18, Number 1.

2008

William G. Bendena, Jeffrey R. BoudreauTony Papanicolaou, Matt Maltby, Stephen S. Tobe  and  Ian D. Chin-Sang (2008). A Caenorhabditis elegans allatostatin/galanin-like receptor NPR-9 inhibits local search behaviour in response to feeding cues. PNAS 105(4):1339-42  [PDF] 

 2007

Sarah E. Brisbin and Ian D. Chin-Sang (2007) Analysis of DAF-18/PTEN in VAB-1 Eph RTK Signaling.  McGill J. Med. 10(2): 157-175.

 2006

Mohamed, A., and Chin-Sang, Ian D. (2006). Characterization of Loss-of-Function and Gain-of-Function Eph Receptor Tyrosine Kinase Signaling in C. elegans axon guidance and cell migration. Developmental Biology 290:1:164-176  [PDF]

 2005

Ghenea, S., Boudreau, J.R., Lague, N.P. and Chin-Sang, Ian D(2005).  The VAB-1 Eph Receptor Tyrosine Kinase and SAX-3/Robo neuronal Receptors function together during C. elegans embryonic morphogenesis. Development 132, 3679-3690 [PDF]

Ian Chin-Sang (2005). The C. elegans VAB-1/Eph receptor tyrosine kinase functions with the SAX-3/Robo receptor during cell movements and axon guidance. Abstract Published in Developmental Biology 283 (2): 575

 older

  • Chin-Sang, Ian D.  Moseley S.L., Ding, M., Harrington, R.J., George, S.E., and Chisholm, A.D. (2002).  The divergent C. elegans ephrin EFN-4 functions in embryonic morphogenesis in a pathway independent of the VAB-1 Eph Receptor. Development 129: 5499-5510 
  • Chin-Sang, Ian D. and Chisholm, Andrew D. (2000). Form of the worm: Genetics of Epidermal Morphogenesis in C. elegans. Trends in Genetics 16:(12) 544-55 [Cover Article]

 

 

  • Chin-Sang, Ian D. George, S.E., Ding, M., Moseley, S.L., Lynch, A., and Chisholm, A.,D.,  (1999). The Ephrin VAB-2/EFN-1 Functions in Neuronal Signaling to Regulate Epidermal Morphogenesis in C. elegans Cell 99: 781-790 
  •  Chin-Sang, Ian D., and Spence, Andrew M., (1996).  C. elegans Sex Determining Protein FEM-2 is a Protein Phosphatase that Promotes Male Development and Interacts Directly with FEM-3.  Genes & Development 10:2314-2325.

Manuscripts in preparation:

  1. Ian D. Chin-Sang and Patrick Hu (in review).  C. elegans cancer genes. Invited book chapter for WormBook.  WormBook, ed. The C. elegans Research Community, WormBook,doi/10.1895/wormbook.1.7.1, http://www.wormbook.org.

Meeting Abstracts:

Platform Sessions (* refers to speaker)

  1. Jeffrey Boudreau  and Ian D. Chin-Sang* (2014). The role of insulin like neuropeptides in C.elegans  axon guidance and behaviour. Upstate New York C. elegans meeting. May 3rd 2014.
  2. Jason Campbell*, Ian D. Chin-Sang and William G. Bendena (2014). A potential role for neuropeptide receptor 9 (npr-9) in the aversive response! Upstate New York C. elegans meeting. May 3rd 2014.
  3. Gabriel Chamberlain* and Ian D. Chin-Sang (2014). What can a worm tell us about cancer? Department of Biology Graduate Research Day. Queen’s University. April 24th 2014.

  4. Jeffrey Boudreau and Ian D. Chin-Sang*:  Insulin-like Neuropeptide Overexpression in C. elegans. Invertebrate Neuropeptides Conference, El Calafate Argentina. March 18 2014.

  5. J.C. Campbell, Ian Chin-Sang and W.G. Bendena* (Queen’s U, Canada) A role for C. elegans neuropeptide receptor-9 (npr-9) within the AIB neuron in the spontaneous reversal pathway. Invertebrate Neuropeptides Conference, El Calafate Argentina. March 18 2014.
  6. Samantha W.S. Lo* and Ian D. Chin-Sang (2013). In Vivo Interactions Between PTP-3 RTP and Various Signaling Pathways in the Nervous System. Upstate New York C. elegans meeting. April 20 2013.
  7. Jun Liu, Jeffrey R. Boudreau, Jordon Taylor and Ian D. Chin-Sang* (2013). A role for C. elegans insulin-like peptide signaling in axon guidance. Invertebrate Neuropeptide Conference, Krabi, Thailand, Feb. 2013
  8. Christine Wang, Ian Chin-Sang, Jeff Boudreau, Tony Papanicolaou and William Bendena *(2011).  Allatostatin-like receptors contribute to foraging behavior in Caenorhabditis elegans and Drosophila melanogaster. Invertebrate Neuropeptide Conference, Sabah, Malaysia, Feb 2011.
  9. Wiliam G. Bendena*, Christine Wang and Ian Chin-Sang (2011).   Allatostatin-like receptors influence behaviour in Drosophila melanogaster and Caenorhabditis elegans. WGB Invited Symposium speaker: Presented at the North American Society for comparative endocrinology meeting, Ann Arbor Michigan, July 2011.
  10. Ahmed M. Mohamed*, Jeffery Boudreau, Jun Liu, Ian D. Chin-Sang. (2011). Genetic and Molecular Characterization of VAB-1 Eph Receptor Signaling in Axon Guidance. 18th International C. elegans Conference UCLA.
  11. Ghenea, S*., Boudreau, J.R. Lague, N. and Ian Chin-Sang. (2005). The VAB-1 Eph Receptor Tyrosine Kinase and SAX-3/Robo Neuronal Receptors Function Together during C. elegans Embryonic Morphogenesis.  15th International C. elegans Conference, University of California, Los Angles California USA.
  12. Andrew Chisholm*, Ian Chin-Sang, Mei Ding, Sean George, Bob Harrington, Tom Holcomb, Kris Larsen, and Sarah Moseley (2004) Cell Signaling Networks in C. elegans Morphogenesis. The Markey Scholars Conference Proceedings, National Academy Press.
  13. Chin-Sang, Ian D*., George, S.E.,Moseley,S., Holcomb,T., Ding, M., and Chisholm,A. (2000). Eph/Ephrin signaling in C. elegans Epidermal and Neuronal Morphogenesis.  Abstract Published in Proceedings of the Tenth Winternational Symposium of the CSBMCB. Volume 78, Number 5,
  14. Ian Chin-Sang*, Sean George, Mei Ding, and Andrew Chisholm (1999).  The Ephrin VAB-2 interacts with the VAB-1 receptor to regulate neural and epidermal morphogenesis.  International C. elegans meeting (June 2-6), University of Wisconsin, Madison WI, USA.
  15. Ian Chin-Sang*, Mei Ding, and Andrew Chisholm (1998).  The Role of the VAB-2 Ephrin in C. elegans development.  West Coast C. elegans meeting (June 27-30), UC Berkeley CA, USA.
  16. Ian Chin-Sang*, and Andrew Chisholm (1998).  The Role of the VAB-2 Ephrin in C. elegans development Mid-West C. elegans meeting, (June 19-21).  University of Chicago, Chicago IL, USA.
  17. Ian D. Chin-Sang*, and Andrew M. Spence, (1996).  Protein-Protein Interactions between FEM-3 and FEM-2, a masculinizing Protein Phosphatase.  Mid-West C. elegans meeting (June 7-9), Illinois State University, Normal, IL, USA.

Posters Presented:

  1. Boris Baitsov, Jason Campbell, Ian D. Chin-Sang, William Bendena (2013). A neuropeptide receptor localized to AIB interneuron works in combination with a neuropeptide to regulate locomotory behaviour in Caenorhabditis elegans. Upstate New York C. elegans meeting. April 20 2013.
  2. Jordon Taylor and Ian D. Chin-Sang (2013). The Role of EFN-1 and DAF-28 in C. elegans Axonal Guidance. Upstate New York C. elegans meeting. April 20 2013.
  3. Gabriel.S. Chamberlain, Michael Zanetti, and Ian D. Chin-Sang (2013). Regulators and germline specific function of DAF-18/PTEN. Upstate New York C. elegans meeting. April 20 2013.
  4.  Fabian P.S. Yu and Ian D. Chin-Sang (2012). Forward and reverse genetic approach to screen for genes that affect VAB-1/Eph RTK in axon guidance of C. elegans. 6th Canadian Dev. Biol. Conference, Banff AB March 8-11th.
  5. Samantha W.S. Lo and Ian D. Chin-Sang (2012)In vivo interactions between PTP-3 RTP and VAB-1 Eph RTK. 6th Canadian Dev. Biol. Conference, Banff AB March 8-11th.
  6. Fabian P.S. Yu, Ahmed M. Mohamed, Ian D. Chin-Sang  (2011).  Characterization of a L1 axon guidance phenotype in the mechanosensory neurons and the role of lethal genes in axon guidance. 18th International C. elegans Meeting University of California, Los Angeles June 22-June 26th.  
  7.  Michael R. Zanetti, Peter E. Hand, Ian D. Chin-Sang (2011). Suppressors of daf-18 L1 arrest phenotype and investigating a role for DAF-18 protein phosphatase activity. 17th International C. elegans Meeting University of California, Los Angeles June 22-June 26th.  [Third Prize Poster Award]
  8. Sarah Brisbin, Jun Liu, Jeffrey Boudreau, Ian Chin-Sang (2009). A Role for C. elegans Eph RTK Signalling in PTEN Regulation.  17th International C. elegans Meeting University of California, Los Angeles June 24-June 29th [First Prize Poster Award]
  9. Ahmed M. Mohamed, Jeffrey Boudreau, Ian D. Chin-Sang (2008).  The Role of NCK-1 in C. elegans Neurodevelopment. Neuronal Development, Synaptic Function & Behavior. C. elegans Topic Meeting #2. University of Wisconsin-Madison. June 29th -July 2nd.
  10. Xin Li, Hongtao Jia, DonHa Park, Ian Chin-Sang, Helen M. Chamberlin (2008). Ephrin singaling acts through Ras/MAPK to promote C. elegans germline cell death. C. elegans Development and Evolution Meeting June 11th -15th University of Wisconsin-Madison.
  11. Jiravat Visanuvimol, Leticia Sánchez Alvarez, Jeffrey Boudreau, Anna Su, Ian Chin-Sang, and Antonio   Colavita1 (2007). 1Planar Cell Polarity (PCP) signaling is involved in multiple aspects of C. elegans development. 16th International C. elegans Meeting University of California, Los Angeles June 27-July1st.
  12. Ahmed M. Mohamed, Jeffrey Boudreau, Ian D. Chin-Sang (2007). The Adaptor Molecule NCK-1 is a Component of the VAB-1 Eph RTK Signaling Pathway. 6th International C. elegans  Meeting University of California, Los Angeles June 27-July1st.
  13. Jun Liu and  Ian Chin-Sang (2007). Identifying intracellular partners of the SAX-3/Robo signaling pathway and the introduction of a novel assay to study membrane protein-protein interactions.  16th International C. elegans  Meeting University of California, Los Angeles June 27-July1st.
  14. Sarah E. Brisbin, and  Ian D. Chin-Sang (2007). Analysis of DAF-18/PTEN in VAB-1 Eph RTK Signaling. 16th International C. elegans  Meeting University of California, Los Angeles June 27-July1st.
  15. Annie Lam, Jadine Paw, Tony Papanicolaou, Ian Chin-Sang (2007) Fhod-2: a struggle to find an identity. University of California, Los Angeles June 27-July1st.
  16. Jun Liu and Ian D. Chin-Sang (2006). Identifying intracellular partners of the C. elegans SAX-3/Robo receptor through a modified yeast two hybrid screen. Santa Cruz Conference on Developmental Biology. Santa Cruz CA USA.
  17. Simona Ghenea, Ahmed M. Mohamed, Jeffrey R. Boudreau and Ian D. Chin-Sang (2006). The role of Eph receptor tyrosine kinase and Robo receptor signaling during C. elegans cell movements and axon guidance.  3rd Canadian Developmental Biology Conference. Mont Tremblant Quebec, Canada.
  18. Simona Ghenea, Jeffrey R Boudreau and Ian D. Chin-Sang (2006).  The Caenorhabditis elegans daf-18   ortholog of the human PTEN tumour suppressor functions during embryonic cell migrations. 3rd Canadian Developmental Biology Conference. Mont Tremblant Quebec, Canada.
  19. Ahmed Mohamed, and Ian D. Chin-Sang (2006). Characterizing the role of the eph receptor tyrosine kinase and ephrin ligands in Caenorhabditis elegans axon targeting, and neuron cell positioning.  3rd Canadian Developmental Biology Conference. Mont Tremblant Quebec, Canada.
  20. David H. Lum, George Lemieux, Simona Ghenea, Ian D. Chin-Sang and Zena Werb (2006). Analysis of   matrix metalloproteinase function in the nematode C. elegans. 3rd Canadian Developmental Biology Conference. Mont Tremblant Quebec, Canada.
  21. Liu Jun and Ian Chin-Sang (2005). Cell culture experiments to characterize a putative VAB-1/Eph RTK and SAX-3/Robo neuronal receptor complex.  15th International C. elegans Conference, University of California, Los Angles California USA.
  22. Ahmed Mohamed and Ian Chin-Sang (2005). The VAB-1 Eph RTK is Required for Proper Axon Guidance and Neuronal Cell Positioning.   15th International C. elegans Conference, University of California, Los Angles California USA.
  23. Jadine Paw and Ian D. Chin-Sang (2004). Functional characterization of vab-6 and F45E10.2, genes involved in Caenorhabditis elegans embryonic and morphogenetic development. 2nd Canadian Developmental Biology Symposia. Banff Alberta, Canada.
  24. Michel Cameron and Ian D. Chin-Sang (2004). Identification of proteins that interact with the VAB-1 receptor tyrosine kinase in Caenorhabditis elegans. 2nd Canadian Developmental Biology Symposia. Banff Alberta, Canada.
  25. Simona Ghenea, and Ian D. Chin-Sang (2004). The VAB-1 Eph RTK signaling pathway interacts with at least three other parallel singling pathways for embryo development. 2nd Canadian Developmental Biology Symposia. Banff Alberta, Canada.
  26. Ian Chin-Sang (2003). Eph Receptor Tyrosine Kinase Signaling in C. elegans Morphogenesis.  2nd annual CIHR New Investigators (by invitation only). Jackson’s Point Ontario.
  27.  Jeffrey R. Boudreau and Ian D. Chin-Sang (2003). The VAB-1 Eph Receptor Tyrosine Kinase Interacts with the C. elegans Tumor Suppressor DAF-18/PTEN and May Regulate PI(3,4,5)P3 Signaling During Neuronal Development. International C. elegans meeting, UCLA, Los Angeles CA, USA.
  28. Ahmed Mohamed, Ian D. Chin-Sang (2003).  A Constitutively Active VAB-1 Eph RTK Causes Defects in Neuronal Morphogenesis. International C. elegans meeting, UCLA, Los Angeles CA, USA. [Award winning]
  29. Ahmed Mohamed and Ian D. Chin-Sang (2003). A C. elegans model to understand neurodevelopment.   Queen's University Health Science Research Day. Queen's University, Kingston ON Canada.
  30. Simona Ghenea and Ian D. Chin-Sang (2002). Ephrin/Eph RTK signaling in C. elegans Morphogenesis.  Santa Cruz Conference on Developmental Biology. Santa Cruz California USA.
  31. Simona Ghenea and Ian D. Chin-Sang (2002).  Ephrin Signaling in C. elegans Morphogenesis.  West Cost C. elegans meeting. UCSD San Diego California.
  32. Chin-Sang, Ian, and Chisholm, Andrew (2001).  The Ephrin EFN-4 may function independently of the VAB-1 Eph Receptor in morphogenesis.  International C. elegans meeting June 22-26, University of California Los Angeles, CA, USA.
  33. Chin-Sang, Ian, McCleery, Julie and Chisholm, Andrew (2000).  Suppressor Analysis of Eph/Ephrin Defective Signaling in C. elegans.  West Coast C. elegans meeting June 23-26, University of California Los Angeles, CA, USA
  34. Chin-Sang, Ian and Spence, Andrew, (1996).  FEM-2 to the Rescue. International C. elegans meeting (June ), University of Wisconsin, Madison WI, USA.
  35. Gaudet, Jeb, Chin-Sang, Ian and Spence, Andrew (1996).  Localizations of FEM Proteins.  International C. elegans meeting (June ), University of Wisconsin, Madison WI, USA.